Novel GxE effects and resilience: A case:control longitudinal study of psychosocial stress with war-affected youth
UKHIH Publication
Connie J. Mulligan, Christopher J. Clukay, Anthony Matarazzo, Kristin Hadfield, Lisa Nevell, Rana Dajani, Catherine Panter-Brick
22
April
2021
Output type
Journal article
Location
Jordan
Focus areas
Mental health and psychosocial support (MHPSS)
Topics
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Programme
Humanitarian Research
Organisations
Yale University
Responses to early life adversity differ greatly across individuals. Elucidating which factors underlie this variation can help us better understand how to improve health trajectories. Here a case:control study of refugee and non-refugee youth, differentially exposed to war-related trauma, is used to investigate the effects of genetics and psychosocial environment on response to trauma. The results point to novel interactions between the protective effects of genetic variants and resilience, lending support to ideas of differential susceptibility and altered stress reactivity in a cohort of war-affected adolescents.
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