Novel GxE effects and resilience: A case:control longitudinal study of psychosocial stress with war-affected youth

Responses to early life adversity differ greatly across individuals. Elucidating which factors underlie this variation can help us better understand how to improve health trajectories. Here a case:control study of refugee and non-refugee youth, differentially exposed to war-related trauma, is used to investigate the effects of genetics and psychosocial environment on response to trauma. The results point to novel interactions between the protective effects of genetic variants and resilience, lending support to ideas of differential susceptibility and altered stress reactivity in a cohort of war-affected adolescents.