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Due to the effects of population growth and increasing urbanization, earthquakes now account for the largest burden of injury among all geophysical disasters, claiming an average of 27,000 lives each year and leaving hundreds of thousands more with serious injuries and long-term disability. (1) Yet despite these trends, and despite increasing calls for an evidence-based approach to disaster management, precious little research has been conducted in the acute phase of a major earthquake.(2) In fact, no prior randomized controlled trials, the gold standard in medical research, have been conducted to evaluate the comparative efficacy of different management strategies for patients with traumatic injuries in the aftermath of a major earthquake.

There are three primary reasons for this major deficiency in the disaster evidence-base: funding, logistics, and ethics.


Until recently, most global health research funding agencies focused their portfolio on communicable diseases, such as HIV, TB, and malaria, with little money set aside for trauma or disaster research in low- and middle-income countries.


In addition, conducting research in the acute phase of a natural disaster such as an earthquake represents a major logistical challenge. Even after receiving grant funding, researchers typically spend months developing their protocols, hiring and training staff, and building their data management system. Acute care research in the aftermath of a major earthquake, however, must be launched within days in order to accomplish its aims.

RAPID research team members undergo pre-deployment training in ultrasound-guided regional anesthesia at MSF-USA headquarters in New York.


Finally, there is the difficulty in obtaining pre-approval for research from a local ethics committee in the country where the research will be conducted when neither the location nor the timing of the disaster are known in advance.

The Regional Anesthesia for Painful Injuries after Disaster (RAPID) study, developed in collaboration between researchers at Epicentre, Médecins Sans Frontières (MSF), and Brown University, seeks to be the first to overcome these barriers and conduct a randomized controlled trial in the aftermath of a major earthquake. Epidemiologic studies from multiple settings consistently show that trauma sustained during earthquakes predominantly affects the lower limbs. (3-4) Regional anesthesia, which involves injecting a small amount of local anesthetic near the femoral nerve in the upper thigh, has already been shown to be effective at reducing pain for patients with hip fractures in high-resource settings.(5) Whether it can also reduce pain for patients with lower limb crush injuries remains unknown, as these types of injuries are uncommon outside of an earthquake setting. Additionally, it is unclear whether ultrasound guidance can improve the efficacy and safety of regional anesthesia in a disaster setting.(6)

To answer these questions, the RAPID study will enroll a cohort of patients presenting to an MSF field hospital with lower limb injuries in the aftermath of a major earthquake and randomize them to one of three treatments: standard care with narcotic pain medication; standard care plus regional anesthesia; or standard care plus ultrasound-guided regional anesthesia. We will then measure the self-reported pain of patients over time to determine whether regional anesthesia can safely and effectively reduce pain in earthquake victims with lower limb injuries.

As we await the appropriate trigger criteria for the launch of the RAPID study (i.e. a major earthquake in a resource-limited setting to which MSF deploys a field response), our team has already worked to overcome the significant barriers noted above.

First, we have obtained advanced funding for our project through Elrha’s Research for Health in Humanitarian Crises (R2HC) Rapid Response Grant, which covers initial start up costs for the research, followed by the release of the remaining funds in the immediate aftermath of a major earthquake. The first of its kind, the R2HC Rapid Response Grant is an important resource for humanitarian and academic research teams wishing to conduct studies in the acute phase of a humanitarian crisis. Second, we have overcome many of the logistical barriers noted above by preparing our study protocols and data collection tools in advance; harmonizing all of our study medications and equipment with those already present in an MSF trauma field hospital; and training a large team of research staff members who can be quickly deployed after an earthquake to carry out the research.

Finally, we obtained pre-approval from the MSF Ethics Review Board for our study. In the event of an earthquake, we will attempt to identify a local ethics committee or governmental health authority within 72 hours and provide them with the opportunity to review our study protocols and prior ethical approval and make any changes they deem necessary.

Conducting high-quality health research in the acute phase of a major disaster presents extraordinary challenges. Through a combination of targeted research funding, strong academic and humanitarian partnerships, and a good deal of advanced planning, however, we believe that these challenges can be overcome. Indeed, we owe it to the millions of people affected by disaster each year to find a way to ensure that they have access evidence-based therapies that have been proven effective for the types of injuries and conditions they are most likely to experience.

  1. Guha-Sapir D, Vos T (2011). Earthquakes, an Epidemiological Perspective on Patterns and Trends. In: Human Casualties in Earthquakes: Progress in Modelling and Mitigation. New York, NY: Springer:13-24
  2. Gerdin M, Clarke M, Allen C, et al. Optimal evidence in difficult settings: improving health interventions and decision making in disasters. PLoS Med 2014; 11: e1001632.
  3. Jacquet GA, Hansoti B, Vu A, Bayram JD. Earthquake-related injuries in the pediatric population: a systematic review. PLoS currents. 2013;5.
  4. Kang P, Zhang L, Liang W, et al. Medical evacuation management and clinical characteristics of 3,255 inpatients after the 2010 Yushu earthquake in China. The journal of trauma and acute care surgery. Jun 2012;72(6):1626-1633.
  5. Beaudoin FL, Haran JP, Liebmann O. A comparison of ultrasound-guided three-in-one femoral nerve block versus parenteral opioids alone for analgesia in emergency department patients with hip fractures: a randomized controlled trial. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine. Jun 2013;20(6):584-591. 6) Walker KJ, McGrattan K, Aas-Eng K, Smith AF. Ultrasound guidance for peripheral nerve blockade. The Cochrane database of systematic reviews. 2009(4):CD006459.

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